三种蒽醌衍生物对小鼠外周血淋巴细胞微核影响

doi:10.3969/j.issn.1004-616x.2000.01.014

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (1): 45-046.doi: 10.3969/j.issn.1004-616x.2000.01.014

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EFFECTS OF SOME ANTHRAQUINONE DERIVATIVES ONMOUSE PERIPHERAL BLOOD LYMPHOCYTE MICRONUCLEUS

CHENG Long-qiu1, LIANG Zhi-cheng1, RU Ming-quan2

1. Departmet of Biotechnique, Jinan University, Guangz hou 　510632, China 　2. Department of Bioloy, Shandong Medical University, Jinan 　250012, China

Received:1900-01-01 Revised:1900-01-01 Online:2000-01-30 Published:2000-01-30

Abstract

Abstract: Purpose and Methods : Most of the information about possible genotoxic effect s of anthraquinone derivatives is derived f rom prokaryotic systems that must differ f rom mammalian systems and human. In this study 1. 5 - diaminoanthraquinone (1. 5 - DAAQ) , 1. 5 - dichloroanthraquinone (1. 5 - DCAQ) and 1. 8 - diahloroanthraquinone (1. 8 - DCAQ) were selected for testing used micronucleus(MN) analysis in BALBC/ c mice peripheral blood lymphocytes. Results : Result s show that they were significant difference f rom second to fifth injection times as compared with the cont rol micronucleus f requency ( P < 0. 01) when those compounds accumulated to a weight of 100mg/ kg. bw following ip in BALBC/ c mice. Conclusion : We suggest there is requirement to research and minitor their mutagenesis.

Key words: anthraquinones derivative, genotoxicity, micronucleus

CLC Number:

CHENG Long-qiu, LIANG Zhi-cheng, RU Ming-quan. EFFECTS OF SOME ANTHRAQUINONE DERIVATIVES ONMOUSE PERIPHERAL BLOOD LYMPHOCYTE MICRONUCLEUS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(1): 45-046.

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EFFECTS OF SOME ANTHRAQUINONE DERIVATIVES ONMOUSE PERIPHERAL BLOOD LYMPHOCYTE MICRONUCLEUS

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